Installation is quite easy as long as you are au fait with standard UNIX utilities. You should ftp to ftp.sanger.ac.uk, log in as anonymous and move to pub/birney/wise2. You can then pick up the release - I would pick up the latest numbered in that directory. (NB, if you want to be working in the development release, go to the pub/birney/wise2/alpha directory, but be sure to read the html help at http://www.sanger.ac.uk/Software/Wise2/Programming).